Tag: Research

  • Is “man flu” a real thing? Here’s what the research says

    Is “man flu” a real thing? Here’s what the research says

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    When it comes to getting a cold or the flu, there is a commonly held belief that men take it harder than women, exaggerating their symptoms and basically acting like big ol’ babies. But is this phenomenon of “man sick” a real thing? We investigate.

    These days, it seems like I can’t get on a transatlantic flight without getting sick. Blanket and pillow? Sure. Headphones? No thanks I have my own. Pretzels? You bet. RSV? COVID? Bronchitis? Well, uh … I guess you just choose because I’ll be taking one off the plane with me.

    Such was my fate after returning to my home in Portugal after attending a wedding in Pennsylvania last week. Pretty much the day we landed, I started to feel achy, sniffly, lousy, and all the other words that end in “y” that indicated I had come down with something. I got a bit yuckier feeling every day physically, but my mood also took a turn for the worse when my wife said she had told some friends that I had to miss a gathering because I was “man sick.”

    “No, I’m legitimately sick,” I thought. But I know the answer would have been, “you’re not really that sick, you’re just behaving like you are.” It’s a conversation we’ve had many times as, I suspect, have many couples. So to try to figure out if I was just being a wimp or if there was something to this gender discrepancy in the way men and women get sick, this science-journalist husband decided to dig into the research.

    Man flu

    This concept of being “man sick” or having the “man flu” has been around for quite a while. According to Wikipedia, “man flu’s” “earliest known use was found in a message posted on the Usenet newsgroup misc.health.diabetes in 1999, as documented by the Oxford English Dictionary.” But is there any legitimate science behind the idea?

    Well, yes and no. As you might imagine when it comes to something as subjective as how you feel when you’re sick, rigorous studies are hard to carry out. That said, there has been some work done on the topic.

    One of the most comprehensive reviews on studies relating to gender differences and immunity was published in the Annual Review of Immunology (ARI) in 2022. That report found that there was indeed quite a bit of difference in how men and women respond to bacterial and viral invaders.

    For starters, the review found that women generally get fewer viral infections than men. Some of this might have to do with the fact that men generally take fewer precautions than women in terms of getting sick such as mask wearing and hand washing. But the ARI paper revealed that there are also significant biological differences for the finding, including the fact that women tend to mount a more robust immune response to viruses.

    After HIV-1 infection, for example, the immune cells known as plasmacytoid dendritic cells (pDCs) from women produce more levels of a chemical known as IFN-α than men do. This cytokine – an inflammation-controlling protein – is a critical component of the antiviral response and women produce it faster than men, meaning they get busy fighting off infections sooner than guys do.

    The study also found that in the face of H1N1 infection, women had higher levels of antibodies in their systems than men. Women were also found to have “more robust memory CD8+T cell responses,” meaning their immune systems would be better equipped to fight off the same viral invader in the future.

    Finally, and perhaps most relevant to my own investigation, the study also found that women tend to have lower viral loads than men when infected with the same bugs, meaning that their symptoms would naturally be less severe.

    Blame Darwin

    Researchers have postulated that there’s both an evolutionary and biological explanation for the stronger immune systems in women. Because many immune-regulating functions come from the X chromosome, it would make sense that women, who have two of them, would have a stronger immune system. Also, some studies have suggested that estrogen boosts immunity while testosterone suppresses it.

    From an evolutionary point-of-view, women’s stronger immune systems make sense, as they need to remain healthy to bear children and raise them without getting themselves or their offspring sick. Once men have done their part in the procreation process, they could just go sulk away in a cave if they got sick and emerge – or not – when they felt better.

    Men and women mount different immune responses when they get a cold, which could explain the different ways they report their symptoms
    Men and women mount different immune responses when they get a cold, which could explain the different ways they report their symptoms

    So there’s some hard-and-fast evidence that men have weaker immune systems than women, therefore get sicker than women, and therefore, likely complain more than women about their illnesses. But the research doesn’t quite back that up either.

    A study reported in the Journal of Psychosomatic Research (JPR) in 2022 found that although women recovered faster from acute rhinosinusitis (ARS) than men, they reported a higher degree of symptoms.

    Likewise, in a 2019 study reported in the British Medical Journal, researchers infected 15 men and 15 women with the E. coli bacteria at a strong enough dose to induce flu-like symptoms. They found that women exhibited a stronger pro-inflammatory response and had low levels of vascular reactivity, which was higher in men. This measure indicates that IV medication would have a better effect on women than men. The key finding though, was that both sexes rated their severity of symptoms identically.

    Moans and groans

    That being said, another study that was reported on in the British Medical Journal looked at 1,700 men and women who had the common cold and found that men did indeed over-rate their symptoms about 6% more than women did.

    But perhaps more interestingly, the researchers reporting on that study conducted one of their own in which they deliberately infected people with an endotoxin that caused them to develop flu-like symptoms. In that study, both sexes reported their symptoms equally and exhibited the same amount of moans and complaints. However, the men tended to have a higher frequency of sighs and deep breaths which could be construed as a higher level of complaining.

    So, IS there such a thing as the man flu?

    It certainly seems that there are reasons why guys get sicker more frequently and have more severe symptoms when they do succumb to a bug. In fact, when it comes to COVID-19 it’s been reported that men had more severe symptoms than women and contracted the virus and died at a rate over 15% higher than women. That’s definitely something worth complaining about.

    But marital jibes aside, my research showed that there’s a more sinister side to suggesting that when men get sick they overreact because, thanks to that stigma, many guys will be hesitant to take their own symptoms seriously and seek medical attention for them, which is a dangerous trend. Or, as the JPR researchers put it …

    “The pop-cultural portrayal of men as overly weak and hysterical patients when facing a simple flu may hinder men from seeking for appropriate medical treatment because of a fear to be ridiculed. To avoid a culture of toxic masculinity, stereotypical portrayals of gender roles should be avoided.”

    Now excuse me while I go curl up in a ball in bed and pass out, because I’m SICK and this article has really wiped me out!



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  • Google’s NotebookLM Now Lets You Customize Its AI Podcasts

    Google’s NotebookLM Now Lets You Customize Its AI Podcasts

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    Google just added a new customization tool for the viral AI podcasts in its NotebookLM software. I got early access and tested it out using Franz Kafka’s The Metamorphosis as the source material, spending a few hours generating podcasts about the seminal novella—some of them more unhinged than others.

    Released by Google Labs in 2023 as an experimental, AI-focused writing tool, NotebookLM has been enjoying a resurgence in user interest since early September, when the developers added an option to generate podcast-like conversations between two AI voices—one male-sounding and one female-sounding—from uploaded documents. While these audio “deep dives” can be used for studying and productivity, many of the viral clips online focused on the entertainment factor of asking robot hosts to discuss bizarre or highly personal source documents, like a LinkedIn profile.

    Raiza Martin, who leads the NotebookLM team inside of Google Labs, is pumped to give users more control over the content of these synthetic podcasts. “It’s the number one feature we’ve heard people request,” she says. “They want to provide a little bit of feedback as to what the deep dive focuses on.” According to Martin, this is the first update of many coming down the pipeline.

    Nearing the one year anniversary of its full launch, NotebookLM is also dropping the “experimental” tag—a sign it’s not headed towards the perpetual Google graveyard of abandoned software, or at least for now. Martin says this label was removed since the team hit internal milestones for overall quality, user retention, and interface standards. She also says users can now expect a higher level of stability from the software.

    How to Customize the AI Podcasts

    To make an AI podcast using NotebookLM, open up the Google Labs website and start a New Notebook. Then, add any source documents you would like to be used for the audio output. These can be anything from files on your computer to YouTube links.

    Next, when you click on the Notebook guide, you’ll now see the option to generate a deep dive as well as the option to customize it first. Choose Customize and add your prompt for how you’d like the AI podcast to come out. The software suggests that you consider what sections of the sources you’d like highlighted, larger topics you want further explored, or different intended audiences who you want the message to reach.

    One tip Martin shares for trying out the new feature is to generate the Audio Overview without changes, and while you’re listening to this first iteration, write down any burning questions you have or topics you wish it expanded on. Afterwards, use these notes as a launching pad to create your prompts for NotebookLM and regenerate that AI podcast with your interests in mind.

    My First Impressions

    I uploaded an 80-page file of Kafka’s famous work of existential literature—in it, the main character wakes up one morning to find that he has turned into a gigantic bug—to see how the customization will work for NotebookLM users. The first Audio Overview it generated, sans prompt customization, was a solid, albeit broad overview of what happens in the novella, as well as some discussion of its key themes. Nothing groundbreaking, but decent.

    Thinking like a nerdy college English major, which I definitely was, my first prompt adjustment was for the podcast discussion to focus more on themes of alienation and overbearing bureaucracy found in the book. With the extra nudge, this output from NotebookLM did an admirable job of zeroing in on these motifs and generating a discussion that sounded similar to what I’ve heard before in college classrooms. It was a bit meandering, but totally listenable.

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  • Apple Engineers Show How Flimsy AI ‘Reasoning’ Can Be

    Apple Engineers Show How Flimsy AI ‘Reasoning’ Can Be

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    For a while now, companies like OpenAI and Google have been touting advanced “reasoning” capabilities as the next big step in their latest artificial intelligence models. Now, though, a new study from six Apple engineers shows that the mathematical “reasoning” displayed by advanced large language models can be extremely brittle and unreliable in the face of seemingly trivial changes to common benchmark problems.

    The fragility highlighted in these new results helps support previous research suggesting that LLMs’ use of probabilistic pattern matching is missing the formal understanding of underlying concepts needed for truly reliable mathematical reasoning capabilities. “Current LLMs are not capable of genuine logical reasoning,” the researchers hypothesize based on these results. “Instead, they attempt to replicate the reasoning steps observed in their training data.”

    Mix It Up

    In “GSM-Symbolic: Understanding the Limitations of Mathematical Reasoning in Large Language Models”—currently available as a preprint paper—the six Apple researchers start with GSM8K’s standardized set of more than 8,000 grade-school level mathematical word problems, which is often used as a benchmark for modern LLMs’ complex reasoning capabilities. They then take the novel approach of modifying a portion of that testing set to dynamically replace certain names and numbers with new values—so a question about Sophie getting 31 building blocks for her nephew in GSM8K could become a question about Bill getting 19 building blocks for his brother in the new GSM-Symbolic evaluation.

    This approach helps avoid any potential “data contamination” that can result from the static GSM8K questions being fed directly into an AI model’s training data. At the same time, these incidental changes don’t alter the actual difficulty of the inherent mathematical reasoning at all, meaning models should theoretically perform just as well when tested on GSM-Symbolic as GSM8K.

    Instead, when the researchers tested more than 20 state-of-the-art LLMs on GSM-Symbolic, they found average accuracy reduced across the board compared to GSM8K, with performance drops between 0.3 percent and 9.2 percent, depending on the model. The results also showed high variance across 50 separate runs of GSM-Symbolic with different names and values. Gaps of up to 15 percent accuracy between the best and worst runs were common within a single model and, for some reason, changing the numbers tended to result in worse accuracy than changing the names.

    This kind of variance—both within different GSM-Symbolic runs and compared to GSM8K results—is more than a little surprising since, as the researchers point out, “the overall reasoning steps needed to solve a question remain the same.” The fact that such small changes lead to such variable results suggests to the researchers that these models are not doing any “formal” reasoning but are instead “attempt[ing] to perform a kind of in-distribution pattern-matching, aligning given questions and solution steps with similar ones seen in the training data.”

    Don’t Get Distracted

    Still, the overall variance shown for the GSM-Symbolic tests was often relatively small in the grand scheme of things. OpenAI’s ChatGPT-4o, for instance, dropped from 95.2 percent accuracy on GSM8K to a still-impressive 94.9 percent on GSM-Symbolic. That’s a pretty high success rate using either benchmark, regardless of whether or not the model itself is using “formal” reasoning behind the scenes (though total accuracy for many models dropped precipitously when the researchers added just one or two additional logical steps to the problems).

    The tested LLMs fared much worse, though, when the Apple researchers modified the GSM-Symbolic benchmark by adding “seemingly relevant but ultimately inconsequential statements” to the questions. For this “GSM-NoOp” benchmark set (short for “no operation”), a question about how many kiwis someone picks across multiple days might be modified to include the incidental detail that “five of them [the kiwis] were a bit smaller than average.”

    Adding in these red herrings led to what the researchers termed “catastrophic performance drops” in accuracy compared to GSM8K, ranging from 17.5 percent to a whopping 65.7 percent, depending on the model tested. These massive drops in accuracy highlight the inherent limits in using simple “pattern matching” to “convert statements to operations without truly understanding their meaning,” the researchers write.

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  • Zaha Hadid Architects Reveals Design for New Scientific Research Centre in Tashkent, Uzbekistan

    Zaha Hadid Architects Reveals Design for New Scientific Research Centre in Tashkent, Uzbekistan

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